Another 12 people, including 10 tourists, were injured in the attack that occurred in the Mariutiya neighborhood of Giza, the statement said.
The bus, which was carrying 14 Vietnamese tourists, passed by a wall in which the bomb was hidden at around 6 p.m. local time, officials said.
A terrorist attack took the lives of two people and injured a dozen more in Egypt Friday; targeting a tourist bus as it made its way towards the country's world-famous ancient pyramids.
The statement added that police located a number of weapons and explosives at the hideouts.
Two of the tourists are critically injured, Acting Prime Minister Sherif Ismail said.
The bus driver and nine other Vietnamese visitors were wounded, reports Efe.
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The white tourist bus could be seen with its windows shattered and surrounded by soot-covered debris.
"The bus deviated from the route secured by the security forces", Madbouly told Extra News channel, an assertion also made by the owner of the company that organized the bus tour.
Madbouly said the Egyptian authorities have been in contact with the embassy of Vietnam.
According to the official state news agency MENA, security forces killed the suspected fighters in raids in Giza and northern Sinai - a volatile desert region that has been a hotbed for various armed groups.
Egyptian Foreign Ministry spokesman Ahmed Hafez called the attack an act of terrorism.
Egypt's government says it is prioritising fighting Islamist militants, as it works to restore stability after years of turmoil following the Arab Spring protests of 2011.