More than 12 inches of snow will fall Sunday in the southern and central Appalachians, the National Weather Service said.
Utility crews and others began fighting the winter storm before it even hit.
More than 300,000 people were affected by electricity outages in the Carolinas, Alabama, Tennessee and Georgia on Sunday, while storm warnings remained in place in the south-east "especially North Carolina and Virginia", the National Weather Service (NWS) said in a tweet.
If you're looking to track the path of this powerful winter storm, I've rounded up a few good resources below for real-time updates and infographics.
A tree fell on a vehicle in Mathews on Sunday afternoon, killing one person, police there said.
The storm has already dumped more than ten inches of snow in part of Texas and caused flooding further south in Houston.
North Carolina Gov. Roy Cooper also declared a state of emergency as the storm approached. In some parts of the state, Cooper said that a year's worth of snow fell in just one day.
As many as 383,341 people were without power in the South East including 246,524 outages in North Carolina and 99,571 in SC, according to Power Outage.US.
American Airlines also issued a travel alert for nine airports throughout the Carolinas, Tennessee, and Virginia.
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McAleenan has been overseeing the USA southern border where more than 7,000 migrants have gathered near Tijuana, Mexico . But they also warned they would stop offering food and medical services at the Benito Juarez sports complex.
In South Carolina, more than 255,600 customers have lost power, according to reports, while around 20,000 and 30,000 customers in Tennessee and Georgia, respectively, are now without electricity.
For areas east of I-95, rain is due to mix with snow later Sunday afternoon.
Flight cancellations and delays continued Monday at Charlotte Douglas International Airport, the sixth busiest airport in the country. The storm will exit early Monday morning.
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About 6 inches of snow had fallen in Durham County as of about 7:30 a.m., according to the sheriff's office.
For Floridians heading to the Carolinas, you might have trouble leaving Central Florida on Monday as 10 flights have been canceled, a lot of them were heading to Charlotte, N.C.
The storm also meant flight cancellations.
In South Carolina, a state known for palmettos rather than freezing rain, ice-covered roads were making driving conditions perilous.
Officials in several states urged residents to stay off the roads and instead enjoy holiday festivities with their loved ones.