Kevin De Bruyne will miss next weekend's Manchester Derby and will be in a race against time to face Chelsea at the start of December after being ruled out for between five and six weeks with a knee injury.
The 27-year-old was forced off in last night's Carabao Cup fourth round win over Fulham after Timothy Fosu-Mensah accidentally landed heavily on his knee.
However, the Belgium global sustained an issue with his opposite knee during a coming together with Timothy Fosu-Mensah, and it has left the playmaker facing another spell on the sidelines.
De Bruyne will now miss next week's Manchester derby, while the midfielder is unlikely to feature during the rest of the Champions League group stages. We want to protect them, help them. that goes for him all of the players in the academy.
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"I think today, Kevin is back", Guardiola said. "But we have to live without him and we have to be there when he comes back, that's all we can do", he told reporters on Friday.
Although De Bruyne, whose wife gave birth to their second child on Wednesday, does not require an operation, he will fly to Barcelona to see specialist Dr Ramon Cagut.
Guardiola said at the final whistle: "He is being checked by the doctors. He can spend time with his family, then it's global break and then he will be back".
John Stones played the whole match against Fulham and could keep his place at centre-back, although Nicolas Otamendi is another option if Guardiola wants to keep the Englishman fresh for next week's Champions League meeting with Shakhtar Donetsk.