The $548 million Mega Millions jackpot numbers were drawn on Friday night as 70, 24, 46, 4, 61 with a Mega Ball of 7.
The estimated $654 million total is the second-highest in the game's history.
No tickets matched all five numbers and the mega number for Tuesday's jackpot worth $470 million.
The jackpot is the third-largest in the game's history and the odds of winning are 302,000,000 to one.
The largest Mega Millions jackpot topped out at $656 million in 2012, followed by $648 million a year later. Those wanting to play can purchase $1 tickets until 10:45 p.m.
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One person in Arkansas did win $3 million Friday by matching all five of the white balls. The most recent Mega Ball was 18 on Tuesday night.
The cash option for Friday night: $309 million. They agreed to split the winnings and continue working.
There were no winners in Saturday night's Powerball drawing, so the next drawing, scheduled for Wednesday, will be worth an estimated $345 million, Powerball officials said.
Mega Millions is available in 44 states, plus the District of Columbia and the U.S. Virgin Islands.