Ferdinand then came up with a great analogy for Messi's style of play: "I think we can talk about Tottenham and their efforts later on but you have to marvel at this guy here".
On the other hand Suarez once again failed to score and has now gone nearly three years without a goal away from home in the Champions League.
"Messi had more space in the second half and that is hard to stop", said the 46-year-old.
Barca pushed for more goal as the second resumed, as Messi rattled the upright twice in the opening five minutes.
After slotting the ball past Hugo Lloris in the 56th minute, Messi ran over to a TV camera behind the goal while pointing.
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On his defenders' performance, the Portuguese said: "They tried, they raised the level of their intensity". We don't have the technical quality to build from the back.
Nobody disputes the genius he showed for the first time more than a decade ago and has demonstrated consistently since but, after so long at the top and having played more than 800 games, we have to accept that nights like these, when he illuminated Wembley, might be less frequent. "Our response was very good", Valverde, under the cosh after Barca drew two and lost one of their last three La Liga games, told reporters. He's just on another level and no player can be compared with him.
"[Messi] was unbelievable. When he's in that form he's magic to watch".
Messi shook his head in disbelief but soon silenced the home crowd again - this time side-footing inside the post from Alba's cross to finish a flowing move he started.
Tottenham improved after the break, and pulled a goal back in the 52nd minute.
He scored one on that occasion, but he made it two against Spurs by burying a chance following another Suarez dummy in the 90th minute.
Spurs twice rallied, making it 2-1 and then 3-2 and almost equalising with a deflected Lucas Moura effort, but Lionel Messi's 90th-minute strike - his second goal of the night - ended Spurs' hopes.
"These are the games you want to be involved in, that you dream of playing in", Trippier said to BT Sport.