Mannarino had returned a long Federer backhand and the Swiss maestro wasted no time in showing off his cricket skills, which captured social media by storm. "I've often said the day that you don't feel nervous is the day you should be more anxious about". "I always enjoy playing against him", said Nishikori, who has beaten the Serb just twice in 15 meetings. So, too, is 19-year-old Denis Shapovalov of Canada.
The top seed took a comfortable 6-0 7-5 6-4 victory against Adrian Mannarino in the fourth round. "I knew he was much better than that first set and I think he showed that".
Novak Djokovic won his battle to be promoted to Centre Court billing for Wednesday's quarter-finals, forcing eight-time champion Roger Federer off the sport's most famous arena for the first time in three years.
Elsewhere in fourth round action, Dominika Cibulkova launched a scathing attack on Wimbledon's officials after a line call controversy marred her 6-4, 6-1 win against Taiwan's Hsieh Su-Wei.
Isner added another 22 aces to his tournament-topping tally that now stands at 135 after the ninth seed's 6-4 7-6 (10-8) 7-6 (7-5) triumph over young Greek sensation Stefanos Tsitsipas.
Thai cave rescue: Operation resumes for remaining 9 who are trapped
The operation was launched at 10 am local time (0400 CET) on Sunday and involves 13 foreign divers and 5 Thai navy SEALs. In letters written by the boys released Saturday, the boys appeared calm and reassured their families they were "fine".
"I actually did get a bit emotional that I was in the last 16 of a Grand Slam that I have been dreaming of winning one day", Tsitsipas said. And none has lost a set in the tournament.
The World Cup showpiece will take place on Sunday at 18:00 (local time), which is 16:00 BST, meaning it is likely to kick off during the men's grass-court final, which eight-time champion Federer is a heavy favourite to be a part of. We are talking about I am in quarter-finals. He also moves like a journeyman heavyweight boxer so it was never going to work out for him unless he flattened out his game on both wings and tried to rush Nadal but he didn't have it in him.
The 28-year-old Nishikori is the first Japanese man to reach the quarterfinals at Wimbledon since Shuzo Matsuoka in 1995. Thereafter it was Federer's familiar playground as he rattled off ridiculously easy wins over Dusan Lajovic, Lukas Lacko, Jan-Lennard Struff and Adrian Mannarino, a Who's Who of "Who?" to many.
On Wednesday on Centre Court, he will start as underdog against Nadal, the 17-time major victor who is in the quarter-finals at Wimbledon for the first time since 2011 when he went on to finish runner-up.
While Williams boasts 23 major championships, the remaining seven women have combined for just three: Angelique Kerber has won two (2016 Australian Open and 2016 U.S. Open) and Jelena Ostapenko one (2017 French Open).