The fearless Uruguay go marching on: The South Americans remain "dark-horses" for World Cup glory, but with four wins out of four, conceding just one goal in the process, they simply can not be overlooked.
The teams will face off at 2 p.m. ET on Saturday in Sochi, Russia, in the 2018 World Cup Round of 16.
But just hours after Messi and Argentina had lost 4-3 to France, Cristiano was also on his way to the airport after his Portugal side lost 2-1 to Uruguay.
For now, it is back to the drawing board for Ronaldo and Portugal, as sights turn to the European Championships in two years' time, and possibly one last World Cup for Ronaldo in 2022.
The World Cup lost its headline acts on Saturday as the game's two biggest stars, Lionel Messi and Cristiano Ronaldo, readied to leave Russian Federation after their teams were eliminated in the round of 16.
It was from another sort of dead-ball delivery that Portugal found a chink in the armour, Pepe equalising with a header from a corner after the break.
Portugal boss Fernando Santos says if Cristiano Ronaldo plays alone we lose
However, they have lost their last three games in the World Cup knockout stages (1 goal scored, 5 conceded). We are going to have to work collectively, but we don't lose sleep over this.
And he managed to score a-not-too-shabby four games in the tournament. Ronaldo started off this year's tournament with a hat trick against Spain and then added another goal against Morocco. "This team will continue to be one of the best in the world, with quality players and a young group who are close together", Ronaldo said.
"In football, there are no moral victories and I would have preferred to play worse and win the match", Portugal coach Fernando Santos said. The quarter-final clash that I might see from the Fisht stadium would feature either Spain or Russian Federation against Croatia or Denmark.
Two-time world champion Uruguay hadn't reached the last eight at the World Cup since a fourth-place finish in 2010.
'And I also want to congratulate the organisation of this World Cup, it has been fantastic in every way; the organisation, the security, the atmosphere is flawless and it must be said.
"That was an incredible play", Santos said.
Portugal unmistakably dictated the game, but despite trying every which way, came up short due to their struggles breaking down the well-organised Uruguay defence.