And the Spaniard has been given a testing opening to Premier League management.
Wenger chose to step down at the end of last season after nearly 22 years in charge of the north London club. This is first time a club has been allowed to play home games at two venues in the same season.
The redeveloped White Hart Lane will not be ready for the start of the season, so their first home game against the Cottagers will be played at the national stadium.
"We are so excited to have the date of the first Premier League match at our new stadium", he said.
City will then make their 2018/19 home bow against newly-promoted Wolverhampton Wanderers a week later.
Judge rules AT&T can purchase Time Warner
The judge's ruling is being seen by tech and telecom giants as a green light to pursue a slew of major media acquisitions. The Justice Department "did a good job just focusing on this merger. and how it would be abusive, not just how bad".
But City, who ended United's long unbeaten run at Old Trafford with a 2-1 win last December, will travel to Old Trafford on March 16 believing that they can take huge step towards retaining their title with another win on enemy territory.
December will see Spurs playing mostly at home with a Boxing Day game against Bournemouth as they host Wolves to finish off the year. The coaching staff were keen to place a home game within the early fixtures so we shall have one home game at Wembley.
The opening Manchester derby of the season takes place at the Etihad on November 10.
However, the Reds are still some way from being a Premier League-winning outfit.
During their impressive march to the UEFA Champions League final in 2017-18, it went slightly unnoticed that Liverpool only narrowly finished in the top four in the Premier League.
Tottenham, who will join City, United and Liverpool in the Champions League next season, begin their campaign at Newcastle for the second successive season before hosting Fulham a week later.