Pierre-Emerick Aubameyang ran onto a long ball into the Newcastle area and picked out Lacazette, who stretched to volley home at the far post for his 13th goal of a hard first season following his move from Lyon.
Newcastle's fourth successive win ended Arsenal's unbeaten run of seven games in all competitions.
Newcastle United came from one goal behind to record a 2-1 win over Arsenal at St James' Park on Sunday.
Rafa Benitez's team passed the 40-point mark widely viewed as a guarantee against relegation and is 13 points clear of third-to-last Southampton with five games remaining.
Trump Lawyer Michael Cohen Joked About His 2.0 GPA, Old Classmate Says
Cohen frequently taped conversations with adversaries and opposing lawyers, according to the two people briefed. Cohen, however, said the officials who conducted the raid had been courteous and professional.
The decision not to bring in the system next season was made at a recent Premier League shareholders meeting in London, when all 20 member clubs voted. However, it won't have given the players any added confidence ahead of their huge Europa League semi-final clash with Atletico Madrid in 10 days time.
Newcastle levelled the scores in the 29th minute, however, when Perez turned a low DeAndre Yedlin cross into the back of the net after Gayle had gathered a long pass from Jonjo Shelvey before delivering wide.
According to BBC, Arsenal, who reached the Europa League semi-finals with a 6-3 aggregate win over CSKA Moscow in Russian Federation on Thursday, are the only team in England's top four divisions yet to earn an away league point in 2018.
Matt Ritchie sent Newcastle into the lead 68 minutes in as Islam Slimani flicked on a header before the Scotsman fired a right-footed strike past Cech from close range.
Lacazette should have equalised in the closing stages, but he shot into the side-netting.